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MilliporeSigma™ anti-DYRK1A Clone: 7D10,

Catalog No. ST1650100UG Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
ST1650100UG 100 μg Unconjugated
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Catalog No. ST1650100UG Supplier MilliporeSigma™ Supplier No. ST1650100UG
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Description

Mouse Monoclonal Antibody

Specifically detects DYRK1A Clone: 7D10 in Human, Mouse, Rat samples, and it is validated for ELISA, Immuno Blotting

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DYRK1A
Applications ELISA, Immunoblot, Immunoblot
Classification Monoclonal
Clone 7D10
Conjugate Unconjugated
Formulation In PBS, pH 7.2.
Host Species Mouse
Immunogen A recombinant polypeptide corresponding to amino acids of 674-763 human DYRK1A, expressed as a GST fusion protein
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽80-85kDa DYRK1A protein in PC-12, 293, HeLa NE, Raw 264.7, and NIH3T3 cells.
Target Species Human, Mouse, Rat
Content And Storage −20°C
Form Purified
Isotype IgG2b
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