MilliporeSigma™ anti-E-cadherin, Clone: EP700Y, ™

Supplier:  MilliporeSigma™ 041103/DEL

Catalog No. 50-171-219

Description

Cadherins are a family of transmembrane glycoproteins involved in Ca²⁺-dependent cell to cell interactions. The members of the family are differentially expressed in various tissues and function in the maintenance of tissue integrity, morphogenesis, and migration. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin), neural cadherin (N-cadherin), placental cadherin (P-cadherin) and retinal cadherin (R-cadherin). Type II include kidney cadherin (K-cadherin) and osteoblast cadherin (OB-cadherin). One of the best characterized cadherins is E-cadherin (epithelial cadherin or cadherin-1). It consists of calcium binding extracellular domains responsible for interactions with other E-cadherin molecules on neighboring cells and interaction with integrin αEβ7. The cytoplasmic domain of E-cadherin is linked to the actin cytoskeleton through cytoplasmic catenin proteins, thus establishing a complex localized to adherens junctions. In carcinomas E-cadherin is frequently downregulated, which is consistent with its function of an invasion suppressor in normal epithelia.

Host Species: Rabbit
Clone: EP700Y
Isotype: IgG
Species Reactivity: Human
Immunogen: Synthetic peptide corresponding to residues in the 5th cadherin domain of human E-cadherin.
Formula Weight [Chemical]: ∽135/80kDa

Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting

Specifications

• Antigen: E-cadherin
• Clone: EP700Y
• Host Species: Rabbit
• Purification Method: Unpurified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Isotype: IgG

• Classification: Monoclonal
• Conjugate: Unconjugated
• Immunogen: Synthetic peptide corresponding to residues in the 5th cadherin domain of human E-cadherin.
• Quantity: 100 μL
• Research Discipline: Cell Structure
• Target Species: Human