Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

EAAT2 (Excitatory amino acid transporter 2; Glutamate transporter 1; GLT1) Mouse anti-Rat, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611654

Catalog No. BDB611654

Add to cart



Electrogenic-coupled (Na+ and K+) glutamate transporters in nerve terminals and glial cells are essential for maintaining subtoxic levels of extracellular excitatory amino acid neurotransmitters (e.g. glutamate and aspartate). They are also important for modifying synaptic transmission through the cotransport of ions and neurotransmitters. Excitatory amino acid transporter 2 (EAAT2) has 8 α-helical transmembrane domains and two reentrant pore-loop-like structures whose conformation is altered during ion neurotransmitter transport. EAAT2 is primarily expressed in astrocytes in adult brain and spinal cord, however it is also found in axons during fetal development. Mice deficient in EAAT2 exhibit lethal epileptic seizures with destruction of hippocampal neurons and an increased susceptibility to cold-induced cortical injury. Such defects in glutamine transporters have also been implicated in stroke, brain trauma, Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease. Thus, glutamine transporters, such as EAAT2, are critical for prevention of neurotoxic brain injury and may regulate glutamatergic synaptic transmission.

Host Species: Mouse
Clone: 20
Isotype: IgG1
Species Reactivity [for Features Main]: Rat
Immunogen: Human EAAT2 aa. 562-574

Immunofluorescence, Western Blotting



EAAT2 (Excitatory amino acid transporter 2; Glutamate transporter 1; GLT1)
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
Western Blot
Excitatory amino acid transporter 2; Glutamate transporter 1; GLT1
Affinity Purified
Human EAAT2 aa. 562-574
Cell Biology
Product Certifications


Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit