EAAT2 (Excitatory amino acid transporter 2; Glutamate transporter 1; GLT1) Mouse anti-Rat, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 611654

Catalog No. BDB611654

Description

Electrogenic-coupled (Na⁺ and K⁺) glutamate transporters in nerve terminals and glial cells are essential for maintaining subtoxic levels of extracellular excitatory amino acid neurotransmitters (e.g. glutamate and aspartate). They are also important for modifying synaptic transmission through the cotransport of ions and neurotransmitters. Excitatory amino acid transporter 2 (EAAT2) has 8 α-helical transmembrane domains and two reentrant pore-loop-like structures whose conformation is altered during ion neurotransmitter transport. EAAT2 is primarily expressed in astrocytes in adult brain and spinal cord, however it is also found in axons during fetal development. Mice deficient in EAAT2 exhibit lethal epileptic seizures with destruction of hippocampal neurons and an increased susceptibility to cold-induced cortical injury. Such defects in glutamine transporters have also been implicated in stroke, brain trauma, Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease. Thus, glutamine transporters, such as EAAT2, are critical for prevention of neurotoxic brain injury and may regulate glutamatergic synaptic transmission.

Host Species: Mouse
Clone: 20
Isotype: IgG1
Species Reactivity [for Features Main]: Rat
Immunogen: Human EAAT2 aa. 562-574

Immunofluorescence, Western Blotting

Specifications

• Antigen: EAAT2 (Excitatory amino acid transporter 2; Glutamate transporter 1; GLT1)
• Classification: Monoclonal
• Concentration: 250μg/mL
• Description: Excitatory amino acid transporter 2; Glutamate transporter 1; GLT1
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

• Applications: Western Blot
• Clone: 20
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Human EAAT2 aa. 562-574
• Quantity: 50 μg
• Research Discipline: Cell Biology
• Target Species: Rat
• Isotype: IgG1