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EAAT2 (Excitatory amino acid transporter 2; Glutamate transporter 1; GLT1) Mouse anti-Rat, Unlabeled, Clone: 20, BD

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BDB611654 50 μg
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Catalog No. BDB611654 Supplier BD Biosciences Supplier No. 611654
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Description

Mouse Monoclonal Antibody

Electrogenic-coupled (Na+ and K+) glutamate transporters in nerve terminals and glial cells are essential for maintaining subtoxic levels of extracellular excitatory amino acid neurotransmitters (e.g. glutamate and aspartate). They are also important for modifying synaptic transmission through the cotransport of ions and neurotransmitters. Excitatory amino acid transporter 2 (EAAT2) has 8 α-helical transmembrane domains and two reentrant pore-loop-like structures whose conformation is altered during ion neurotransmitter transport. EAAT2 is primarily expressed in astrocytes in adult brain and spinal cord, however it is also found in axons during fetal development. Mice deficient in EAAT2 exhibit lethal epileptic seizures with destruction of hippocampal neurons and an increased susceptibility to cold-induced cortical injury. Such defects in glutamine transporters have also been implicated in stroke, brain trauma, Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease. Thus, glutamine transporters, such as EAAT2, are critical for prevention of neurotoxic brain injury and may regulate glutamatergic synaptic transmission.

Host Species: Mouse
Clone: 20
Isotype: IgG1
Species Reactivity [for Features Main]: Rat
Immunogen: Human EAAT2 aa. 562-574

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen EAAT2 (Excitatory amino acid transporter 2; Glutamate transporter 1; GLT1)
Applications Western Blot
Classification Monoclonal
Clone 20
Concentration 250μg/mL
Conjugate Unconjugated
Description Excitatory amino acid transporter 2; Glutamate transporter 1; GLT1
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human EAAT2 aa. 562-574
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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