EBP50 Mouse anti-Human, Clone: EBP-10, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119291
For use in Western blot applications, MA1-19291 should be placed in a vertical incubator for 60 minutes. A suggested positive control for this product is RAJI human lymphoma cell lysate.NHERF1 (Na+/H+ exchanger regulatory factor 1), also known as EBP50 (ezrin, radixin, moesin-binding phosphoprotein 50) is an adaptor protein, which associates with beta-catenin and is required for its localization at the cell-cell junctions, interacts with various G protein-coupled receptors and regulates their traffic, as well as sodium-hydrogen exchange and sodium-dependent phosphate transport. NHERF1/EBP50 inhibits cell motility and is required to suppress anchorage-independent growth. It contains C-terminal ERM (ezrin, radixin, moesin)-binding region and two N-terminal PDZ (postsynaptic-density-95/disc-large/ZO1 homology) domains and is able to form head-to-tail intramolecular conformation to regulate its interactions.
|PBS with 15mM sodium azide; pH 7.4|
|4° C, do not freeze|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|Bacterially produced, recombit, full-length human NHERF1.|
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