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elF4E (pS209) Mouse, PE, Clone: J77-925, BD

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BDB560229 50 Tests
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Catalog No. BDB560229 Supplier BD Biosciences Supplier No. 560229

Description

Mouse Monoclonal Antibody

The eukaryotic translation Initiation Factor 4E (eIF4E) is a 25kDa phosphoprotein that specifically binds to the 7-methylguanosine-containing cap of mRNA. eIF4E is the rate-limiting component for the initiation of cap-dependent translation by the eIF4F translation initiation complex, which is composed of eIF4E, eIF4G, and eIF4A. This complex promotes the unwinding of secondary structure at the 5′ untranslated region of mRNA that is necessary to expose and locate the AUG initiation codon. Other functions of eIF4E have been identified, such as promoting the export of mRNAs that are involved in cell cycle progression from the nucleus and differentially regulating the translation of certain mRNAs in the cytoplasm. Three mechanisms for eIF4E regulation have been identified: Mnk1-mediated phosphorylation on serine 209 (S209) is required for eIF4E binding to the cap structure; over-expression of phosphorylated eIF4E can lead to increased cell proliferation, suppression of apoptosis, and a transformed phenotype; and interactions with nonphosphorylated eIF4E-binding proteins inhibit the formation of the eIF4F complex. The J77-925 monoclonal antibody recognizes the phosphorylated S209 (pS209) of eIF4E.

Host Species: Mouse
Clone: J77-925
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Phosphorylated Human eIF4E Peptide

Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen elF4E (pS209)
Applications Flow Cytometry
Classification Monoclonal
Clone J77-925
Conjugate PE
Description eIF-4E, CBP, EIF4E1, EIF4EL1, EIF4F, mRNA cap-binding protein
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human eIF4E Peptide
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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