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Elk-1 (pS383) Mouse, Alexa Fluor 647, Clone: M21-1721, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 560413

Catalog No. BDB560413


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Description

Description

Elk-1 is a 62kDa member of the Ets oncogene family of transcription factors and a member of the subfamily of ternary complex factors (TCF). Ets proteins mediate a variety of gene activities in response to serum and growth factors. Proteins in the TCF subfamily form a ternary complex by binding to the Serum Response Element (SRE) in conjunction with a dimer of Serum Response Factors (SRF). Elk-1 is phosphorylated by mitogen-activated protein (MAP) kinase pathways in vivo at a cluster of S/T motifs at its carboxy-terminus.
Phosphorylation at these sites, particularly at serine 383 (S383), is critical for Elk-1 transcriptional activation. Studies have shown that Elk-1 is a direct target of activated MAP kinase, and that it is also a target of the stress-activated kinase SAPK/JNK. The M21-1721 monoclonal antibody recognizes the phosphorylated S383 of activated Elk-1. The orthologous phosphorylation sites of mouse and rat Elk-1 are S384 and S382, respectively.

Host Species: Mouse
Clone: M21-1721
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Phosphorylated Human Elk-1 Peptide

Intracellular Staining

TRUSTED_SUSTAINABILITY
Specifications

Specifications

Elk-1 (pS383)
Monoclonal
Alexa Fluor 647
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Phosphorylated Human Elk-1 Peptide
50 Tests
Cell Biology
Human, Mouse, Rat
IgG1 κ
Flow Cytometry
M21-1721
ELK1
Mouse
Affinity Purified
RUO
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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