ERK (pan ERK) Mouse, Unlabeled, Clone: 16, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 610123

Catalog No. BDB610123

Description

The family of serine/threonine kinases known as ERKs (extracellular signal regulated kinases) or MAPKs (mitogen-activated protein kinases) are activated after cell stimulation by a variety of hormones and growth factors. Cell stimulation induces a signaling cascade that leads to phosphorylation of MEK (MAPK/ERK kinase) which, in turn, activates ERK via tyrosine and threonine phosphorylation. A myriad of proteins represent the downstream effectors for the active ERK and implicate it in the control of cell proliferation and differentiation, as well as regulation of the cytoskeleton. Activation of ERK is normally transient and cells possess dual specificity phosphatases that are responsible for its down-regulation. Furthermore, multiple studies have shown that elevated ERK activity is associated with some cancers. ERK1 may be observable migrating at 44kDa and ERK2 at 42kDa in addition to a 54kDa ERK and a MAP kinase in the 90kDa range.

Host Species: Mouse
Clone: 16
Isotype: IgG2a
Species Reactivity: Mouse
Immunogen: Rat ERK2 aa. 219-358
Formula Weight [Chemical]: 42-85kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: ERK (pan ERK)
• Classification: Monoclonal
• Concentration: 250μg/mL
• Description: Extracellular signal Regulated Kinases
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

• Applications: Western Blot
• Clone: 16
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Rat ERK2 aa. 219-358
• Quantity: 50 μg
• Research Discipline: Cell Biology
• Target Species: Canine, Chicken, Frog, Human, Mouse, Rat
• Isotype: IgG2a

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.