ERK (pan ERK) Mouse, Unlabeled, Clone: 16, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610124
The family of serine/threonine kinases known as ERKs (extracellular signal regulated kinases) or MAPKs (mitogen-activated protein kinases) are activated after cell stimulation by a variety of hormones and growth factors. Cell stimulation induces a signaling cascade that leads to phosphorylation of MEK (MAPK/ERK kinase) which, in turn, activates ERK via tyrosine and threonine phosphorylation. A myriad of proteins represent the downstream effectors for the active ERK and implicate it in the control of cell proliferation and differentiation, as well as regulation of the cytoskeleton. Activation of ERK is normally transient and cells possess dual specificity phosphatases that are responsible for its down-regulation. Furthermore, multiple studies have shown that elevated ERK activity is associated with some cancers. ERK1 may be observable migrating at 44kDa and ERK2 at 42kDa in addition to a 54kDa ERK and a MAP kinase in the 90kDa range.
Host Species: Mouse
Species Reactivity: Mouse
Immunogen: Rat ERK2 aa. 219-358
Formula Weight [Chemical]: 42-85kDa
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
|ERK (pan ERK)|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|Extracellular signal Regulated Kinases|
|Rat ERK2 aa. 219-358|
|Canine, Chicken, Frog, Human, Murine, Rat|
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