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ERK1 Mouse, Unlabeled, Clone: MK12, BD

Mouse Monoclonal Antibody

$528.50

Specifications

Antigen ERK1
Clone MK12
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610031
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BD Biosciences
610031
150 μg
Each of 1 for $528.50
Only null left
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Description

Description

The family of serine/threonine kinases known as ERKs (extracellular signal regulated kinases) or MAPKs (mitogen-activated protein kinases) is activated after cell stimulation by a variety of hormones and growth factors. Cell stimulation induces a signaling cascade that leads to phosphorylation of MEK (MAPK/ERK kinase) which, in turn, activates ERK via tyrosine and threonine phosphorylation. A myriad of proteins represent the downstream effectors for the active ERK and implicate it in the control of cell proliferation and differentiation, as well as regulation of the cytoskeleton. Activation of ERK is normally transient and cells possess dual specificity phosphatases that are responsible for its down-regulation. Furthermore, multiple studies have shown that elevated ERK activity is associated with some cancers. ERK1 is a 44 kDa member of the ERK family and shares 85% homology with ERK2 (42 kDa).
Specifications

Specifications

ERK1
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
MK12
Western Blot
Unconjugated
RUO
Canine, Chicken, Frog, Human, Mouse, Rat
Rat ERK1 aa. 325 to 345
Primary
Store undiluted at -20°C.
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