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  6. ERK2 Mouse, Unlabeled, Clone: 33, BD

ERK2 Mouse, Unlabeled, Clone: 33, BD

Catalog No. BDB610103 Shop All BD Biosciences Products
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Catalog No. Quantity
BDB610103 50 μg
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Catalog No. BDB610103 Supplier BD Biosciences Supplier No. 610103

Description

Mouse Monoclonal Antibody

The family of serine/threonine kinases known as ERKs (extracellular signal regulated kinases) or MAPKs (mitogen-activated protein kinases) are activated after cell stimulation by a wide variety of hormones and growth factors. Cell stimulation induces a signaling cascade that leads to phosphorylation of MEK (MAPK/ERK kinase) which, in turn, activates ERK via tyrosine and threonine phosphorylation. Structural analysis of ERK2 indicates that phosphorylation induces a conformational change that exposes the active site for substrate binding. Myriad proteins represent the downstream effectors for the active ERK and implicate it in the control of cell proliferation and differentiation, as well as regulation of the cytoskeleton. Activation of ERK is normally transient and cells possess dual specificity phosphatases that are responsible for its down-regulation. Furthermore, multiple studies have shown that elevated ERK activity is associated with some cancers. ERK2 is the 42kDa member of the ERK family and is highly homologous to ERK1.

Host Species: Mouse
Clone: 33
Isotype: IgG2b
Species Reactivity: Rat
Immunogen: Rat ERK2 aa. 219-358
Formula Weight [Chemical]: 42kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen ERK2
Applications Western Blot
Classification Monoclonal
Clone 33
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Rat ERK2 aa. 219-358
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Chicken, Frog, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG2b
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For Research Use Only.

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