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Espin Mouse, Unlabeled, Clone: 31, BD

Catalog No. BDB611656 Shop All BD Biosciences Products
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BDB611656 50 μg
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Catalog No. BDB611656 Supplier BD Biosciences Supplier No. 611656

Description

Mouse Monoclonal Antibody

Actin-binding proteins regulate the polymerization and depolymerization of actin, connect actin-based structures to membranes and to other cytoskeletal elements, power the movement of actin filaments, and cross-link actin filaments into bundles. Espins are actin binding and bundling proteins. The two isoforms of espin are the 30kDa small espin found in brush border cells and the 110kDa espin found in testis. Espin contains eight ankyrin repeats in the N-terminal region, two proline-rich peptides, an ATP/GTP binding P-loop domain, and a C-terminal actin bundling domain. Small espin is composed of the C-terminal actin bundling domain and a unique region at the N-terminus. Espin binds to actin with a higher affinity than small espin and is more efficient at actin bundling. During spermiogenesis, espin accumulates, along with forming parallel actin bundles, at the ectoplasmic specialization. These actin bundles anchor and position the spermatid within the seminiferous epithelium. Other actin binding proteins, such as α-actinin, vinculin, and fimbrin, have also been implicated in the formation of ectoplasmic specialization, however espin appears to function specifically in the testes.

Host Species: Mouse
Clone: 31
Isotype: IgG2a
Species Reactivity [for Features Main]: Rat
Immunogen: Rat espin aa. 458-580

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Espin
Applications Western Blot
Classification Monoclonal
Clone 31
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Rat espin aa. 458-580
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Chicken, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG2a
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