MilliporeSigma™ anti-Estrogen Receptor α (C1355), Polyclonal, ™ (Upstate™)

Supplier:  MilliporeSigma™ 06935/DEL

Catalog No. 50-172-167

Description

Estrogen Receptor alpha is a 65kDa protein and a member of the steroid family of nuclear receptors. Estrogen Receptor alpha is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change that allows dimerization and binding to estrogen response element sequences. When bound to DNA, Estrogen Receptor alpha can positively or negatively regulate gene transcription. Like other steroid hormone receptors, Estrogen Receptors are intracellular proteins. Estrogen Receptors play an important role in regulating mammary gland growth and differentiation. Breast tumors that are ER positive may also show a more favorable response to anti-estrogen therapies. GenBank Number: NM_000125. UniProt Number: P03372 (Human). MW: 66kDa.

Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: Estrogen Receptor α (C1355)
• Conjugate: Unconjugated
• Immunogen: Peptide representing the last 15 amino acids of rat estrogen receptor α (ERα) (TYYIPPEAEGFPNTI)
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Serum

• Classification: Polyclonal
• Host Species: Rabbit
• Quantity: 200 μL
• Research Discipline: Epigenetics
• Target Species: Mouse, Rat
• Isotype: IgG