MilliporeSigma anti-Excitatory Amino Acid Transporter (GLT-1), Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma PC154100UL
Specifically detects Excitatory Amino Acid Transporter (GLT-1) Clone: in Rat samples, and it is validated for ImmunoprecipitationPrecise regulation of excitatory amino acids (EAA) such as glutamate is essential, as glutamate is not only the major excitatory neurotransmitter, but also a potent excitotoxin. Defects in functional glutamate transport have been identified in the amyotrophic lateral sclerosis (ALS) brain and spinal cord, suggesting that defective glutamate transport may contribute to motor neuron degeneration. Three glutamate transporter subtypes have been identified in mammals, which include GLAST, GLT-1 and EAAC1. More recently, the homologous proteins EAAT1, EAAT2, and EAAT3 have been characterized in humans, respectively. EAAT4 and EAAT5 transporters have been localized to Purkinje cell synapses, and retina, respectively. The selective loss of glutamate transport in ALS appears to be specific for the GLT-1 (EAAT2) transporter subtyp. While GLT-1, GLAST and EAAC1 share approximately 50% sequence homology, the sequence used as the immunogen is unique to GLT-1.
|Excitatory Amino Acid Transporter (GLT-1)|
|a synthetic peptide (NGKSADCSVEEEPWKREK) corresponding to amino acids at the C-terminus of rat GLT-1|
|Serum diluted in PBS.|
|Recognizes the ∽75kDa and the ∽50kDa forms of GLT-1.|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok
For Research Use Only