Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ anti-Excitatory Amino Acid Transporter (GLT-1), Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC154100UL

Catalog No. PC154100UL


Add to cart

Description

Description

Specifically detects Excitatory Amino Acid Transporter (GLT-1) Clone: in Rat samples, and it is validated for Immunoprecipitation

Precise regulation of excitatory amino acids (EAA) such as glutamate is essential, as glutamate is not only the major excitatory neurotransmitter, but also a potent excitotoxin. Defects in functional glutamate transport have been identified in the amyotrophic lateral sclerosis (ALS) brain and spinal cord, suggesting that defective glutamate transport may contribute to motor neuron degeneration. Three glutamate transporter subtypes have been identified in mammals, which include GLAST, GLT-1 and EAAC1. More recently, the homologous proteins EAAT1, EAAT2, and EAAT3 have been characterized in humans, respectively. EAAT4 and EAAT5 transporters have been localized to Purkinje cell synapses, and retina, respectively. The selective loss of glutamate transport in ALS appears to be specific for the GLT-1 (EAAT2) transporter subtyp. While GLT-1, GLAST and EAAC1 share approximately 50% sequence homology, the sequence used as the immunogen is unique to GLT-1.
Specifications

Specifications

Excitatory Amino Acid Transporter (GLT-1)
Unconjugated
Diluted Serum
a synthetic peptide (NGKSADCSVEEEPWKREK) corresponding to amino acids at the C-terminus of rat GLT-1
100μL
−20°C
Polyclonal
Rat
Immunoprecipitation
Serum diluted in PBS.
Rabbit
IgG
RUO
Primary
Recognizes the ∽75kDa and the ∽50kDa forms of GLT-1.
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only