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Ezrin (pT567) Mouse, Unlabeled, Clone: J37-954.281.307, BD

Catalog No. BDB558357 Shop All BD Biosciences Products
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BDB558357 0.1 mg
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Catalog No. BDB558357 Supplier BD Biosciences Supplier No. 558357

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Mouse Monoclonal Antibody

Ezrin is a member of the ERM (Ezrin-Radixin-Moesin) family of proteins that can function as a crosslinker between the actin cytoskeleton and the plasma membrane of the cell. Phosphorylation of threonine residues (Thr567 on Ezrin, Thr564 on Radixin and Thr558 on Moesin) has been reported to occur with stimulation of growth factors and is important for cytoskeletal rearrangements. Phosphorylation of Thr567 at the C-terminal F actin-binding domain has been reported to activate the conversion of Ezrin from a dormant soluble form in the cytosol to a membrane- and actin-binding conformation. In addition to its reactivity to the human species, the peptide used to generate this antibody is either identical or has homology to analogous regions of mouse and rat Ezrin, Radixin and Moesin. The J37-954.281.307 monoclonal antibody has been reported to recognize phosphorylated T567 on active Ezrin in addition to crossreacting on phosphorylated T564 on Radixin and phosphorylated T558 on Moesin.

Immunohistochemistry, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Ezrin (pT567)
Applications Western Blot
Classification Monoclonal
Clone J37-954.281.307
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Ezrin Peptide
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at 4°C
Isotype IgG1 κ
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