F11 Receptor Mouse anti-Human, Unlabeled, Clone: M.AB.F11, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 552147

Catalog No. BDB552147

Description

Reacts with the F11 receptor (also known as JAM-1), an integral membrane protein duplex of 32-35kDa expressed on platelets, leukocytes, red blood cells, endothelial cells, epithelial cells, and various cell lines. The F11R is homologous with the murine protein called Junctional Adhesion Molecule (JAM), a member of the immunoglobulin superfamily. Monoclonal antibody (mAb) F11 is a stimulatory antibody, namely, the binding of F11 mAb to F11R induces morphological changes, granular secretion, and aggregation in human platelets that are mediated by two pathways. Antibody-induced platelet aggregation and granule secretion are dependent on both molecules of FcγRII and GPIIb/IIIa integrin, and that may play a role in some thrombocytopenias. F11R-mediated platelet adhesion and aggregation are not dependent on FcγRII or GPIIb/IIIa and that may play a role in normal platelet physiological processes.

Host Species: Mouse
Clone: M.Ab.F11
Isotype: IgG1 κ
Species Reactivity: Human

Flow Cytometry

Specifications

• Antigen: F11 Receptor
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: JAM-1; Platelet F11 receptor; F11R; JAM-A; PAM-1
• Host Species: Mouse
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Flow Cytometry
• Clone: M.AB.F11
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

For Research Use Only.