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F11 Receptor Mouse anti-Human, PE, Clone: M.AB.F11, BD

Catalog No. BDB552556 Shop All BD Biosciences Products
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BDB552556 100 Tests
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Catalog No. BDB552556 Supplier BD Biosciences Supplier No. 552556
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Description

Mouse Monoclonal Antibody

Reacts with the F11 receptor (also known as JAM-1), an integral membrane protein duplex of 32-35kDa expressed on platelets, leukocytes, red blood cells, endothelial cells, epithelial cells, and various cell lines. The F11R is homologous with the murine protein called Junctional Adhesion Molecule (JAM), a member of the immunoglobulin superfamily. Monoclonal antibody (mAb) F11 is a stimulatory antibody, namely, the binding of F11mAb to F11R induces morphological changes, granular secretion, and aggregation in human platelets that are
mediated by two pathways. Antibody-induced platelet aggregation and granule secretion are dependent on both molecules of FcγRII and GPIIb/IIIa integrin, and that may play a role in some thrombocytopenias. F11R-mediated platelet adhesion and aggregation are not dependent on FcγRII or GPIIb/IIIa and that may play a role in normal platelet physiological processes.

Host Species: Mouse
Clone: M.Ab.F11
Isotype: IgG1 κ
Species Reactivity: Human

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen F11 Receptor
Applications Flow Cytometry
Classification Monoclonal
Clone M.AB.F11
Conjugate PE
Description JAM-1; Platelet F11 receptor; F11R; JAM-A; PAM-1
Formulation Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Host Species Mouse
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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