F4/80-Like Receptor Rat anti-Mouse, Alexa Fluor 647, Clone: 6F12, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 564226
The 6F12 antibody reacts with a 7-transmembrane-domain protein, which is similar to the F4/80 macrophage antigen of the EGF-TM7 protein family and is encoded by the Emr4 gene. The FIRE protein is expressed on myeloid cells with a denditic cell (DC) developmental potential, including subsets of DC and macrophages in the spleen and lymph nodes, most resident peritoneal macrophages, many peripheral blood monocytes, and a subpopulation of bone-marrow myeloid-cell progenitors. The protein is not detected on peripheral T and B lymphocytes, and it is down-regulated on thioglycollate-elicited peritoneal macrophages and on dendritic cells activated by GM-CSF, IFN- γ, anti-CD40, and LPS. Using soluble biotinylated fusion protein, a FIRE ligand was detected on a mouse IgG+ B lymphoma cell line (A20), but not on myeloid, fibroblast, or T-cell lines, suggesting that the FIRE protein may be involved in immunoregulatory interactions between antigen-presenting cells and B lymphocytes.
|Alexa Fluor 647|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Fire; Emr4; EGF-like module receptor 4; D17Ertd479e; Egf-tm7|
|CHO cells expressing recombinant FIRE fusion protein|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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