Factor VIII Mouse anti-Human, Clone: F8 2.2.9, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA110587
MA1-10587 detects the fulll length of Factor VIII from human samples. This antibody does not cross-react with von Willebrand factor. MA1-10587 has been successfully used in ELISA and Western blot applications. The MA1-10587 immunogen is purified human Factor VIII.This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
|PBS with no preservative; pH 7.4|
|RP11-115M6.7, AHF, DXS1253E, F8B, F8C, FVIII, HEMA|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Western Blot|
|Purified human Factor VIII.|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok