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FADD Mouse anti-Human, Unlabeled, Clone: 1, BD

Mouse Monoclonal Antibody

$287.50 - $526.00

Specifications

Antigen FADD
Clone 1
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610399
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BD Biosciences
610399
50 μg
Each for $287.50
Only null left
Add to Cart
 
BDB610400
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BD Biosciences
610400
150 μg
Each for $526.00
Only null left
Add to Cart
 
Description

Description

During apoptosis, cells exhibit morphological signs of the death process: cell shrinkage, membrane blebbing, and chromatin condensation. The role of the cell surface cytokine receptor, Fas (Apo-1, CD95), in apoptosis has been well characterized. The tumor necrosis factor receptor (TNF-R) can trigger cell death, as well as various other responses. Data suggested that Fas and TNF-R affect a common target in the cell death pathway. This target has been identified as FADD, a novel protein that contains a death domain homologous to the death domains of Fas and TNF-R1. FADD specifically binds to Fas, an association mediated by their homologous death domains. Overexpression of FADD induces apoptosis that is inhibited by CrmA, a poxvirus protein that blocks both Fas- and TNF-induced cell death. Thus, FADD is a central element of the Fas-mediated cell death pathway.

This antibody is routinely tested by western blot analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Specifications

Specifications

FADD
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
1
Western Blot
Unconjugated
RUO
Human
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Store undiluted at -20°C.
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