FADD (pS194) Mouse anti-Human, Unlabeled, Clone: J119-857.36, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 558370

Catalog No. BDB558370

Description

During apoptosis, cells exhibit morphological signs of the death process: cell shrinkage, membrane blebbing, and chromatin condensation. The role of the cell surface cytokine receptor, Fas (Apo-1, CD95), in apoptosis has been well characterized. The tumor necrosis factor (TNF) receptor type I (TNFRI, CD120a) and TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2, DR5) can trigger cell death, as well as various other responses. Fas, TNFRI, and TRAILR2 affect a common target in the cell death pathway, FADD (Fas-Associated via Death Domain or FAS-Associating protein with Death Domain, also known as MORT1). FADD is an adaptor protein that specifically binds to Fas and other death domain-containing proteins via their homologous death domains. FADD also contains an N-terminal Death Effector Domain (DED) that interacts with the DED-containing procaspases-8 and -10 to initiate apoptosis. The role of FADD serine 194 (S194) phosphorylation in the regulation of apoptosis and cell cycle progression is under investigation. The J119-857.36 monoclonal antibody recognizes the phosphorylated S194 of human FADD.

Western Blotting

Specifications

• Antigen: FADD (pS194)
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Isotype: IgG1

• Applications: Western Blot
• Clone: J119-857.36
• Conjugate: Unconjugated
• Immunogen: Phosphorylated peptide of the region including serine 194 of human FADD
• Quantity: 0.1 mg
• Research Discipline: Cell Biology
• Target Species: Human