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FADD (pS194) Mouse anti-Human, Unlabeled, Clone: J119-857.36, BD

Catalog No. BDB558370 Shop All BD Biosciences Products
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BDB558370 0.1 mg
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Catalog No. BDB558370 Supplier BD Biosciences Supplier No. 558370

Description

Mouse Monoclonal Antibody

During apoptosis, cells exhibit morphological signs of the death process: cell shrinkage, membrane blebbing, and chromatin condensation. The role of the cell surface cytokine receptor, Fas (Apo-1, CD95), in apoptosis has been well characterized. The tumor necrosis factor (TNF) receptor type I (TNFRI, CD120a) and TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2, DR5) can trigger cell death, as well as various other responses. Fas, TNFRI, and TRAILR2 affect a common target in the cell death pathway, FADD (Fas-Associated via Death Domain or FAS-Associating protein with Death Domain, also known as MORT1). FADD is an adaptor protein that specifically binds to Fas and other death domain-containing proteins via their homologous death domains. FADD also contains an N-terminal Death Effector Domain (DED) that interacts with the DED-containing procaspases-8 and -10 to initiate apoptosis. The role of FADD serine 194 (S194) phosphorylation in the regulation of apoptosis and cell cycle progression is under investigation. The J119-857.36 monoclonal antibody recognizes the phosphorylated S194 of human FADD.

Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen FADD (pS194)
Applications Western Blot
Classification Monoclonal
Clone J119-857.36
Concentration 0.5mg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Phosphorylated peptide of the region including serine 194 of human FADD
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Isotype IgG1
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