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FAIM Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520312

Catalog No. PIPA520312


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Description

Description

A suggested positive control is human spleen tissue lysate. PA5-20312 can be used with blocking peptide PEP-0432.

The susceptibility of primary splenic B cells to Fas-mediated apoptosis is regulated in a receptor-specific fashion. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic proteins Bcl-xL, FLIP, and a recently identified protein termed FAIM. This molecule is broadly expressed in various tissues and exists in at least three isoforms. It is thought that resistance to Fas killing via increased expression of FAIM protects foreign antigen-specific B cells during interactions with FasL-bearing T cells whereas autoreactive B cells are deleted via Fas-dependent cytotoxicity. More recent results have indicated that FAIM interacts with both Trk and p75 neurotrophin receptor and may play a role in promoting neurite outgrowth in different neuronal systems by a mechanism involving the activation of NF-kappa-B and the Ras-ERK pathway.
Specifications

Specifications

FAIM
Polyclonal
PBS with 0.02% sodium azide
Q9NVQ4, Q9WUD8
FAIM1; fas apoptotic inhibitory molecule 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
23873, 55179
Western Blot
Unconjugated
FAIM
Liquid
FAIM
A 14 amino acid peptide from near the carboxy terminus of human FAIM.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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