FAIM Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520312
A suggested positive control is human spleen tissue lysate. PA5-20312 can be used with blocking peptide PEP-0432.The susceptibility of primary splenic B cells to Fas-mediated apoptosis is regulated in a receptor-specific fashion. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic proteins Bcl-xL, FLIP, and a recently identified protein termed FAIM. This molecule is broadly expressed in various tissues and exists in at least three isoforms. It is thought that resistance to Fas killing via increased expression of FAIM protects foreign antigen-specific B cells during interactions with FasL-bearing T cells whereas autoreactive B cells are deleted via Fas-dependent cytotoxicity. More recent results have indicated that FAIM interacts with both Trk and p75 neurotrophin receptor and may play a role in promoting neurite outgrowth in different neuronal systems by a mechanism involving the activation of NF-kappa-B and the Ras-ERK pathway.
|PBS with 0.02% sodium azide|
|FAIM1; fas apoptotic inhibitory molecule 1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|A 14 amino acid peptide from near the carboxy terminus of human FAIM.|
|Antigen affinity chromatography|
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