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FAK Mouse, Unlabeled, Clone: 77/FAK, BD

Catalog No. BDB610087 Shop All BD Biosciences Products
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Catalog No. BDB610087 Supplier BD Biosciences Supplier No. 610087
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Description

Mouse Monoclonal Antibody

Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that colocalizes with integrins in focal adhesions. This cellular localization is directed by a 125 amino acid sequence at the C-terminus called the “Focal Adhesion Targeting sequence” (FAT). The binding of extracellular matrix ligands to integrins triggers autophosphorylation and activation of FAK. This creates binding sites for SH2 domains of intracellular signaling molecules such as src, PI3 kinase, and Grb2. FAK's ability to bind numerous structural and signaling proteins via a variety of interactions has led to substantial speculation about its function. Although FAK's precise role has not been elucidated, proposed possibilities include regulating cell motility, cell growth, cytoskeletal organization, and adhesion-dependent cell survival.

Host Species: Mouse
Clone: 77
Isotype: IgG1
Species Reactivity: Human
Immunogen: Chicken FAK aa. 354-533
Formula Weight [Chemical]: 116-125kDa

Bioimaging, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen FAK
Applications Western Blot
Classification Monoclonal
Clone 77/FAK
Concentration 250μg/mL
Conjugate Unconjugated
Description Focal Adhesion Kinase
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Chicken FAK aa. 354-533
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Chicken, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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