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FAK Mouse, Unlabeled, Clone: 77/FAK, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610088

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Catalog No. BDB610088


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Description

Description

Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that colocalizes with integrins in focal adhesions. This cellular localization is directed by a 125 amino acid sequence at the C-terminus called the “Focal Adhesion Targeting sequence” (FAT). The binding of extracellular matrix ligands to integrins triggers autophosphorylation and activation of FAK. This creates binding sites for SH2 domains of intracellular signaling molecules such as src, PI3 kinase, and Grb2. FAK's ability to bind numerous structural and signaling proteins via a variety of interactions has led to substantial speculation about its function. Although FAK's precise role has not been elucidated, proposed possibilities include regulating cell motility, cell growth, cytoskeletal organization, and adhesion-dependent cell survival.

Host Species: Mouse
Clone: 77
Isotype: IgG1
Species Reactivity: Human
Immunogen: Chicken FAK aa. 354-533
Formula Weight [Chemical]: 116-125kDa

Bioimaging, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

FAK
77/FAK
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Focal Adhesion Kinase
Affinity Purified
Chicken FAK aa. 354-533
150μg
Cell Biology
Primary
Canine, Chicken, Human, Murine, Rat
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