Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

FAK (pY397) (Focal Adhesion Kinase) Mouse anti-Human, Unlabeled, Clone: 14, BD

Mouse Monoclonal Antibody

$350.00 - $555.00


Antigen FAK (pY397) (Focal Adhesion Kinase)
Clone 14
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
View Documents
BD Biosciences
50 μg
Each for $350.00
Add to Cart
View Documents
BD Biosciences
150 μg
Each for $555.00
Add to Cart


Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that colocalizes with integrins in focal adhesions. This cellular localization is directed by a 125 amino acid sequence at the C-terminus called the “Focal Adhesion Targeting” sequence (FAT). The binding of extracellular matrix ligands to integrins triggers autophosphorylation at Tyr-397, and activation of FAK through phosphorylation of Tyr residues (Tyr-576 and Tyr577) in the kinase domain activation loop. For example, cell adhesion to a fibronectin substratum involves concurrent activation of Src and phosphorylation of the FAK activation loop. In addition, phosphorylation of other Tyr residues (Tyr-925, and Tyr-861) creates binding sites for SH2 domains of intracellular signaling molecules such as Src, PI3 kinase, and Grb2. FAK's ability to bind numerous structural and signaling proteins via a variety of interactions is important for FAK activation level, and for FAK interaction with a variety of substrates localized to sites of cell adhesion. Thus, FAK activity is regulated by a complex set of phosphorylation sites, and thisphospho-regulation could be important for cell motility, cell growth, cytoskeletal organization, and adhesion-dependent cell survival.

Host Species: Mouse
Clone: 14
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human FAK (pY397) Peptide

Immunofluorescence, Western Blotting



FAK (pY397) (Focal Adhesion Kinase)
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Affinity Purified
Focal Adhesion Kinase (pY397)
Western Blot
Human FAK (pY397) Peptide
Store undiluted at -20°C.


Product Certifications

For Research Use Only.

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit