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FAK (pY397) (Focal Adhesion Kinase) Mouse anti-Human, Unlabeled, Clone: 14, BD

Mouse Monoclonal Antibody

$310.00 - $490.00

Specifications

Antigen FAK (pY397) (Focal Adhesion Kinase)
Isotype IgG1
Immunogen Human FAK (pY397) Peptide
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611722
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BD Biosciences
611722
50μg Each for $310.00
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BDB611723
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BD Biosciences
611723
150μg Each for $490.00
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Description

Description

Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that colocalizes with integrins in focal adhesions. This cellular localization is directed by a 125 amino acid sequence at the C-terminus called the “Focal Adhesion Targeting” sequence (FAT). The binding of extracellular matrix ligands to integrins triggers autophosphorylation at Tyr-397, and activation of FAK through phosphorylation of Tyr residues (Tyr-576 and Tyr577) in the kinase domain activation loop. For example, cell adhesion to a fibronectin substratum involves concurrent activation of Src and phosphorylation of the FAK activation loop. In addition, phosphorylation of other Tyr residues (Tyr-925, and Tyr-861) creates binding sites for SH2 domains of intracellular signaling molecules such as Src, PI3 kinase, and Grb2. FAK's ability to bind numerous structural and signaling proteins via a variety of interactions is important for FAK activation level, and for FAK interaction with a variety of substrates localized to sites of cell adhesion. Thus, FAK activity is regulated by a complex set of phosphorylation sites, and thisphospho-regulation could be important for cell motility, cell growth, cytoskeletal organization, and adhesion-dependent cell survival.

Host Species: Mouse
Clone: 14
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human FAK (pY397) Peptide

Immunofluorescence, Western Blotting

Specifications

Specifications

FAK (pY397) (Focal Adhesion Kinase)
Human FAK (pY397) Peptide
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Focal Adhesion Kinase (pY397)
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
14
250μg/mL
Store undiluted at -20°C.

For Research Use Only.

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