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Description
A novel protein tyrosine phosphatase, Fap-1 (for FAS-associated phosphatase, originally designated PTP-BAS), has been shown to associated with the carboxy terminus fifteen amino acids of FAS. Three isoforms of the protein result from alternative RNA splicings, the longest of which encodes a protein 2485 amino aicds in lenghth. Although lacking a transmembrane region, Fap-1 does contain a membrane-binding domain, similar to that found in cytoskeleton-associated proteins such as ezrin. Fap-1 does not seem to associate with CD40 or death domain proteins such as TNF-RI and TNF-RII.
Host Species: Rabbit
Cross Reactivity: Human. Others not tested.
Epitope: aa 2290-2491
Immunogen: Recombinant protein encoding aa 2290-2491 of human FAP-1.
Molecular Weight: 280kDa
Positive Control: Placenta
Cellular Localization: Cytoplasmic
Immunohistochemistry (Formalin/Paraffin)
Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly
Specifications
Specifications
| Antigen | FAP-1/FAS-Associated Phosphatase |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Host Species | Rabbit |
| Immunogen | Recombinant protein encoding aa 2290-2491 of human FAP-1. |
| Purification Method | Placenta |
| Quantity | 100 μL |
| Primary or Secondary | Primary |
| Target Species | Human |
| Content And Storage | 2–8 degrees |
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