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FNTA Rabbit anti-Canine, Chicken, Human, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141328

Catalog No. 01-675-665


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Description

Description

Principal Names: Farnesyltransferase, CAAX box (FNTA); alphaCAAX farnesyltransferase alpha subunit, FPTA, FTase-alpha, GGTase-I-alpha,  Protein farnesyl transferase/ geranyl geranyl transferase type I alpha subunit(PGGT1A), Ras proteins prenyl transferase alpha, Type I protein geranyl-geranyl transferase alpha subunit;  Official Gene Symbol: FNTA Gen Bank Accession Number: NP_002018, Gene ID: 2339 (human) Gene Map Locus: 8p11 (human) Prenylation is a common intracellular posttranslational protein modification catalyzed by prenyltransferases. The best characterized among these prenyltransferases is the CAAX farnesyl transferase (2.5.1.21), which is alpha-beta heterodimeric enzyme. It catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box. FNTA or the alpha subunit of farnesyl transferase is shared by the geranyl-geranyl protein transferases. Apart from transfer of farnesyl and geranyl groups to proteins, FNTA has been proposed to regulate intracellular signaling pathways involving p21ras. Reports have shown that FNTA interacts with TGF-beta and activin-type I receptors.

Suggested positive control: mouse colon cell lysate.
Specifications

Specifications

FNTA
Polyclonal
Unconjugated
PBS with 0.2% gelatin and 0.05% sodium azide
P49354, Q04631
CAAX box
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
2339, 25318, 427299, 475566
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
1-3ug/mL
FNTA
Liquid
FNTA
Synthetic peptide corresponding to residues 150-250 of human farnesyltransferase.
Protein G
RUO
Antibody
Polyclonal
Canine, Chicken, Human, Non-human primate, Rat
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