FAS, Mouse, Clone: 2D8, Abnova™

Catalog No.	Quantity
89-016-180	100 μg

Catalog No. 89-016-180 Supplier Abnova Corporation Supplier No. H00000355M03

Description

Mouse monoclonal antibody raised against a partial recombinant FAS.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq

Sequence: SKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINC

Specifications

• Antigen: FAS
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 2D8
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a partial recombinant FAS.
• Formulation: PBS with no preservative; pH 7.4
• Gene: FAS
• Gene Accession No.: NM_000043
• Gene Alias: ALPS1A/APO-1/APT1/CD95/FAS1/FASTM/TNFRSF6
• Gene Symbols: FAS
• Host Species: Mouse
• Immunogen: FAS (NP_000034, 20 a.a. ∼ 119 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 355
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ