fibrillarin, Mouse, Clone: 3E10, Abnova™

Catalog No.	Quantity
89-000-643	100 μg

Catalog No. 89-000-643 Supplier Abnova Corporation Supplier No. H00002091M09

Description

Mouse monoclonal antibody raised against a full-length recombinant FBL.

This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq

Sequence: MKPGFSPRGGGFGGRGGFGDRGGRGGRGGFGGGRGRGGGFRGRGRGGGGGGGGGGGGGRGGGGFHSGGNRGRGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDTTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN

Specifications

• Antigen: fibrillarin
• Applications: ELISA
• Classification: Monoclonal
• Clone: 3E10
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a full length recombinant FBL.
• Formulation: PBS with no preservative; pH 7.4
• Gene: FBL
• Gene Accession No.: BC019260
• Gene Alias: FIB/FLRN/RNU3IP1
• Gene Symbols: FBL
• Host Species: Mouse
• Immunogen: FBL (AAH19260.1, 1 a.a. ∼ 321 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Whole Molecule: Yes
• Primary or Secondary: Primary
• Gene ID (Entrez): 2091
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Isotype: IgG2a κ