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FBP Mouse, Unlabeled, Clone: 6, BD

Catalog No. BDB611286 Shop All BD Biosciences Products
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BDB611286 50 μg
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Catalog No. BDB611286 Supplier BD Biosciences Supplier No. 611286

Description

Mouse Monoclonal Antibody

The c-myc proto-oncogene is an essential participant in regulation of normal cell proliferation and programmed cell death. The far-upstream FUSE Binding Protein (FBP) is one of many factors that bind to a single strand of DNA in the 5′ region of the c-myc gene. FBP, FBP2, and FBP3 comprise a family of single-strand DNA binding proteins that possess many features found in more conventional transcription factors. All FBP proteins bind specifically to a single strand of FUSE via a centrally located DNA binding domain and all contain a potent C-terminal transactivation domain. The transactivation domain of FBP contains three motif copies composed of tyrosine diads. However, a single tyrosine motif is sufficient to activate transcription. The N-terminal portion of FBP can repress the C-terminal transactivation potential. This repression is thought to be mediated by interactions between N- and C-terminal domains that produce an inactive conformation. Although FBP2 and FBP3 exhibit no specific pattern of expression, FBP expression mimics that of c-myc. These data implicate FBP as a transcription factor that is important for the regulation of cell growth and differentiation.

Host Species: Mouse
Clone: 6
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human FBP aa. 61-180
Formula Weight [Chemical]: 74kDa

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen FBP
Applications Western Blot
Classification Monoclonal
Clone 6
Concentration 250μg/mL
Conjugate Unconjugated
Description FUSE Binding Protein
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human FBP aa. 61-180
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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