FBP Mouse, Unlabeled, Clone: 6, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611286
The c-myc proto-oncogene is an essential participant in regulation of normal cell proliferation and programmed cell death. The far-upstream FUSE Binding Protein (FBP) is one of many factors that bind to a single strand of DNA in the 5′ region of the c-myc gene. FBP, FBP2, and FBP3 comprise a family of single-strand DNA binding proteins that possess many features found in more conventional transcription factors. All FBP proteins bind specifically to a single strand of FUSE via a centrally located DNA binding domain and all contain a potent C-terminal transactivation domain. The transactivation domain of FBP contains three motif copies composed of tyrosine diads. However, a single tyrosine motif is sufficient to activate transcription. The N-terminal portion of FBP can repress the C-terminal transactivation potential. This repression is thought to be mediated by interactions between N- and C-terminal domains that produce an inactive conformation. Although FBP2 and FBP3 exhibit no specific pattern of expression, FBP expression mimics that of c-myc. These data implicate FBP as a transcription factor that is important for the regulation of cell growth and differentiation.
Host Species: Mouse
Species Reactivity: Human
Immunogen: Human FBP aa. 61-180
Formula Weight [Chemical]: 74kDa
Immunofluorescence, Western Blotting
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|FUSE Binding Protein|
|Human FBP aa. 61-180|
|Canine, Human, Murine, Rat|
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