FBXW7 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA522805
Suggested positive control: antigen standard for FBXW7 (transient overexpression lysate).Fbw7/Cdc4 is a member of the F box protein family which are characterized by an approximately 40 amino acid motif, the F box. The F box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F box), which function in phosphorylation-dependent ubiquitination. The F box proteins are divided into 3 classes: Fbws containing WD40 domains, Fbls containing leucine rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. Fbw7 belongs to the Fbws class; in addition to an F box, this protein contains 7 tandem WD40 repeats. It binds directly to cyclin E and probably targets cyclin E for ubiquitin mediated degradation. Mutations of this gene are detected in ovarian and breast cancer cell lines. Alternative splicing of this gene generates 2 transcript variants diverging at the 5 ft. termini.
|Synthetic peptide corresponding to the N terminus of the 69 kDa isoform of the hCdc4 protein.|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila), F-box protein FBW7, F-box protein FBX30, F-box protein SEL-10, F-box/WD repeat-containing protein 7, hAgo, hCdc4, homolog of C elegans sel-10|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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