Fcµ Receptor Mouse anti-Human, Alexa Fluor 647, Clone: HM14-1 (also known as HM14), BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 563535
The HM14-1 monoclonal antibody specifically binds to the FAIM3-encoded high affinity receptor for IgM (also known as, Fcµ Receptor, FcλR, Fc mu receptor, Immunoglobulin mu Fc receptor, FcmR, IgM Fc receptor). The FcλR is a type 1 transmembrane glycoprotein that contains an extracellular Ig-like domain with sequence similarities to Fcα/λR and pIgR. It is likewise known as Fas apoptotic inhibitory molecule 3, TOSO or Regulator of Fas-induced apoptosis Toso based on its capacity to counter apoptosis mediated by Fas/CD95 (or TNF) in some experimental model systems. FcλRs are expressed by B cells, CD4+ T cells, CD8+ T cells, and NK cells and are highly expressed on Chronic Lymphocytic Leukemia cells. FcλRs may play roles in cellular activation, antigen presentation and IgM-dependent cell-mediated cytotoxicity. The relatively long cytoplasmic tail of FcλR contains several conserved tyrosine and serine residues. These get phosphorylated after FcλR ligation with IgM immune complexes and may initiate signaling responses. Lymphocyte FcλRscan mediate the internalization of IgM-bound antigens including microbial and viral antigens. This in turn may cause cellular activation due to subsequent antigen processing and exposure of activating ligands to intracellular receptors including Toll-like receptors. The HM7-10 antibody, a related FcµR-specific antibody, reportedly recognizes an epitope near the IgM ligand binding site of the FcµR whereas the HM14-1 antibody does not. oll-like receptors. The HM7-10 antibody, a related FcλR-specific antibody, reportedly recognizes an epitope near the IgM ligand binding site of the FcλR whereas the HM14-1 antibody does not.
|HM14-1 (also known as HM14)|
|FcμR; FcmR; Fc mu receptor; IgM Fc receptor; FAIM3; TOSO|
|Human IgM Fc Receptor Transfected Cell Line|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Alexa Fluor 647|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
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