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Fcμ Receptor Mouse anti-Human, PE, Clone: HM14-1, BD

Catalog No. BDB563017 Shop All BD Biosciences Products
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BDB563017 50 Tests
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Catalog No. BDB563017 Supplier BD Biosciences Supplier No. 563017

Description

Mouse Monoclonal Antibody

The HM14-1 monoclonal antibody specifically binds to the FAIM3-encoded high affinity receptor for IgM (also known as, Fcµ Receptor, FcλR, Fc mu receptor, Immunoglobulin mu Fc receptor, FcmR, IgM Fc receptor). The FcλR is a type 1 transmembrane glycoprotein that contains an extracellular Ig-like domain with sequence similarities to Fcα/λR and pIgR. It is likewise known as Fas apoptotic inhibitory molecule 3, TOSO or Regulator of Fas-induced apoptosis Toso based on its capacity to counter apoptosis mediated by Fas/CD95 (or TNF) in some experimental model systems. FcλRs are expressed by B cells, CD4+ T cells, CD8+ T cells, and NK cells and are highly expressed on Chronic Lymphocytic Leukemia cells. FcλRs may play roles in cellular activation, antigen presentation and IgM-dependent cell-mediated cytotoxicity. The relatively long cytoplasmic tail of FcλR contains several conserved tyrosine and serine residues. These get phosphorylated after FcλR ligation with IgM immune complexes and may initiate signaling responses. Lymphocyte FcλRscan mediate the internalization of IgM-bound antigens including microbial and viral antigens. This in turn may cause cellular activation due to subsequent antigen processing and exposure of activating ligands to intracellular receptors including Toll-like receptors. The HM7-10 antibody, a related FcμR-specific antibody, reportedly recognizes an epitope near the IgM ligand binding site of the FcμR whereas the HM14-1 antibody does not.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Fcμ Receptor
Applications Flow Cytometry
Classification Monoclonal
Clone HM14-1
Conjugate PE
Description FcμR; FcmR; Fc mu receptor; IgM Fc receptor; FAIM3; TOSO
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human IgM Fc Receptor Transfected Cell Line
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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