Fcμ Receptor Mouse anti-Human, PE, Clone: HM7-10, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 563019

Catalog No. BDB563019

Description

The HM7-10 monoclonal antibody specifically binds to the FAIM3 -encoded high affinity receptor for IgM (also known as, Fcµ Receptor, FcµR, Fc mu receptor, Immunoglobulin mu Fc receptor, FcmR, IgM Fc receptor). The FcµR is a type 1 transmembrane glycoprotein that contains an extracellular Ig-like domain with sequence similarities to Fc α /µR and pIgR. It is likewise known as Fas apoptotic inhibitory molecule 3, TOSO or Regulator of Fas-induced apoptosis Toso based on its capacity to counter apoptosis mediated by Fas/CD95 (or TNF) in some experimental model systems. FcµRs are expressed by B cells, CD4+ T cells, CD8+ T cells, and NK cells and are highly expressed on Chronic Lymphocytic Leukemia cells. FcµRs may play roles in cellular activation, antigen presentation and IgM-dependent cell-mediated cytotoxicity. The relatively long cytoplasmic tail of FcµR contains several conserved tyrosine and serine residues. These get phosphorylated after FcµR ligation with IgM immune complexes and may initiate signaling responses. Lymphocyte FcµRs can mediate the internalization of IgM-bound antigens including microbial and viral antigens. This in turn may cause cellular activation due to subsequent antigen processing and exposure of activating ligands to intracellular receptors including Toll-like receptors. The HM7-10 antibody reportedly recognizes an epitope near the IgM ligand binding site of the FcµR whereas, a related FcµR-specific antibody, HM14-1 antibody does not. The HM7 epitope is sensitive to IgM ligand binding.

Specifications

• Antigen: Fcμ Receptor
• Classification: Monoclonal
• Conjugate: PE
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Immunogen: Human IgM Fc Receptor Transfected Cell Line
• Quantity: 50 Tests
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: HM7-10
• Description: FcμR; FcmR; Fc mu receptor; IgM Fc receptor; FAIM3; TOSO
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG2b κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov