Fcµ Receptor Mouse anti-Human, Brilliant Violet 421, Clone: HM14-1, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 564714
The HM14-1 monoclonal antibody specifically binds to the FAIM3 -encoded high affinity receptor for IgM (also known as, Fcµ Receptor, FcλR, Fc mu receptor, Immunoglobulin mu Fc receptor, FcmR, IgM Fc receptor). The FcλR is a type 1 transmembrane glycoprotei n that contains an extracellular Ig-like domain with sequence similarities to Fcα/λR and pIgR. It is likewise known as Fas apoptotic inhibitory molecule 3, TOSO or Regulator of Fas-induced apoptosis Toso based on its capacity to counter apoptosis mediated by Fas/CD95 (or TNF) in some experimental model systems. FcλRs are expressed by B cells, CD4 + T cells, CD8+ T cells, and NK cells and are highly expressed on Chronic Lymphocytic Leukemia cells. FcλRs may play roles in cellular activation, antigen presentation and IgM-dependent cell-mediated cytotoxicity. The relatively long cytoplasmic tail of FcλR contains several conserved tyrosine and serine residues. These get phosphorylated after FcλR ligation with Ig M immune complexes and may initiate signaling responses. Lymphocyte FcλRs can mediate the internalization of IgM-bound antigens including microbial and viral antigens. This in turn may cause cellular activation due to subsequent antigen processing and exposure of activating ligands to intracellular receptors including Toll-like receptors. The HM7-10 antibody, a related FcµR-specific antibody, reportedly recognizes an epitope near the IgM ligand binding site of the FcµR whereas the HM14-1 antibody does not.
The antibody was conjugated to BD Horizon BV421 which is part of the BD Horizon Brilliant Violet family of dyes. With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue filter set (eg, 450/50-nm filter). BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates.
|FcμR; FcmR; Fc mu receptor; IgM Fc receptor; FAIM3; TOSO|
|Human IgM Fc Receptor Transfected Cell Line|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Brilliant Violet 421|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide|
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