Fe65 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1752
PA1-752 detects Fe65 from purified mouse samples. This antibody does not detect endogenous levels of Fe65. PA1-752 has been successfully used in Western blot procedures. By Western blot, this antibody detects an 97 kDa protein representing Fe65 from immunopurified mouse brain lysate. The PA1-752 immunizing peptide corresponds to amino acid residues 352-369 from mouse Fe65. This peptide (Cat. No. PEP-200) is available for use in neutralization and control experiments.The major transcript of the Fe65 gene is a neuron-specific mRNA that encodes a nuclear protein whose amino-terminal domain strongly activates the transcription of reporter genes. Fe65 has been implicated in a regulatory and cell signaling mechanism because it contains two different motifs involved in protein binding; a WW domain (a variant of Src homology 3 domains) and a phosphotyrosine interaction domain (PID). Interestingly, the PID domain binds to the same motif present in the conserved cytoplasmic domains of the beta PP and beta PP-like proteins. RNA analyses revealed that Fe65 is predomitly expressed in the brain and in the regions most affected by Alzheimer’s disease-associated neuropathology.
|Synthetic Peptide: P(352) Q E E E K L S Q R N A N P G I K C(369)|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|O00213, Q9QXJ1, P46933|
|-20° C, Avoid Freeze/Thaw Cycles|
|11785, 29722, 322|
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