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Fe65 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1752

Catalog No. PA1752


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Description

Description

PA1-752 detects Fe65 from purified mouse samples. This antibody does not detect endogenous levels of Fe65. PA1-752 has been successfully used in Western blot procedures. By Western blot, this antibody detects an 97 kDa protein representing Fe65 from immunopurified mouse brain lysate. The PA1-752 immunizing peptide corresponds to amino acid residues 352-369 from mouse Fe65. This peptide (Cat. No. PEP-200) is available for use in neutralization and control experiments.

The major transcript of the Fe65 gene is a neuron-specific mRNA that encodes a nuclear protein whose amino-terminal domain strongly activates the transcription of reporter genes. Fe65 has been implicated in a regulatory and cell signaling mechanism because it contains two different motifs involved in protein binding; a WW domain (a variant of Src homology 3 domains) and a phosphotyrosine interaction domain (PID). Interestingly, the PID domain binds to the same motif present in the conserved cytoplasmic domains of the beta PP and beta PP-like proteins. RNA analyses revealed that Fe65 is predomitly expressed in the brain and in the regions most affected by Alzheimer’s disease-associated neuropathology.
Specifications

Specifications

Fe65
Polyclonal
Unconjugated
APBB1
Liquid
APBB1
Synthetic Peptide: P(352) Q E E E K L S Q R N A N P G I K C(369)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
O00213, Q9QXJ1, P46933
APBB1
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
11785, 29722, 322
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