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Fibronectin Mouse, Unlabeled, Clone: 10, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 610078

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Catalog No. BDB610078


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Description

Description

The 240kDa dimeric fibronectin protein exists in two forms: a soluble protomer in body fluids and an insoluble multimer in the extracellular matrix. The latter is the primary functional form and creates a substrate for cell migration, a role which makes fibronectin vital to embryogenesis and wound response. Fibronectin mediates cytoskeletal organization, cell attachment, and cellular signaling through interactions with cellular receptors. Although various isoforms of fibronectin are derived by alternative splicing, they share a common N-terminus which is a critical region for cell surface binding in an initial step of multimer assembly. Further polymerization steps are regulated by fibronectin/integrin interactions and result in generation of the complex fibrils that constitute the fibronectin matrix.

Host Species: Mouse
Clone: 10
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Fibronectin
Formula Weight [Chemical]: 240kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY
Specifications

Specifications

Fibronectin
Monoclonal
250μg/mL
FN; LETS
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Flow Cytometry
10
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human Fibronectin
150 μg
Cell Biology
Bovine, Canine, Chicken, Human, Mouse, Rat
IgG1 κ
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