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FLI-1 Mouse anti-Human, Unlabeled, Clone: G146-254, BD

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BDB554267 0.1 mg
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Catalog No. BDB554267 Supplier BD Biosciences Supplier No. 554267
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Description

Mouse Monoclonal Antibody

Fli-1 is a 50kDa ets-related transcription factor. Like other ets-related proteins it binds to consensus sites in DNA through a 85 amino acid ets domain in the carboxyl region of the protein. Fli-1 is associated with Ewing sarcoma through at (11;22)(q24;q12) chromosomal translocation. This translocation brings the 5' region of the EWS gene into conjunction with the 3' region of the Fli-1 gene encoding the ets-DNA binding domain. Such a translocation is found in 85% of Ewing sarcomas. The resulting fusion protein has the DNA binding activity of Fli-1 and, with the EWS domain, it is also a more potent transcriptional activator than Fli-1 itself. The strong transforming activity of the EWS-Fli-1 fusion protein may in part be due to its ability to trans-activate the promoter for c-myc. C-myc is known to be elevated in Ewing sarcomas. Clone G146-254 was raised against a bacterially expressed Fli-1 ets domain fusion protein.

Host Species: Mouse
Clone: G146-254
Isotype: IgG2a
Species Reactivity: Human
Immunogen: Fli-1 ets Domain Fusion Protein
Formula Weight [Chemical]: 50kDa

Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen FLI-1
Applications Western Blot
Classification Monoclonal
Clone G146-254
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Fli-1 ets Domain Fusion Protein
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG2a
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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