Invitrogen™ FNIP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520691

Catalog No. PIPA520691

Description

A suggested positive control is mouse skeletal muscle tissue lysate. PA5-20691 can be used with blocking peptide PEP-0806.

FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship.

Specifications

• Antigen: FNIP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FNIP2
• Gene Alias: D630023B12Rik; FNIP1-like protein; Fnip2; Fnipl; folliculin interacting protein 2; folliculin-interacting protein 2; KIAA1450; MAPO1; mKIAA1450; O6-methylguanine-induced apoptosis 1 protein; RGD1562174
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 310538, 329679, 57600
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q80TD3, Q9P278
• Gene Symbols: FNIP2
• Immunogen: An 18 amino acid peptide near the amino terminus of human FNIP2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG