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FoxP3 Mouse anti-Human, Alexa Fluor 488, Clone: 236A/E7, BD

Catalog No. BDB561181 Shop All BD Biosciences Products
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BDB561181 100 Tests
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Catalog No. BDB561181 Supplier BD Biosciences Supplier No. 561181
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Description

Mouse Monoclonal Antibody

The 236A/E7 antibody reacts with the human FoxP3 (Forkhead box protein P3) transcription factor, a member of the forkhead or winged helix family of transcription factors. The expression of FoxP3, also known as Scurfin, IPEX and JM2, has been found to be associated with CD4+ CD25+ regulatory T cells and represents a specific marker for these cells. Flow cytometric analysis has shown that FoxP3 is expressed by the majority of CD4+ CD25+ (high) T cells in peripheral blood while less than half of CD4+ CD25+ (intermediate) cell population are FoxP3 positive. Approximately 5-10% of peripheral CD4+ cells are CD4+ CD25+ T regulatory cells. T regulatory cells are thought to play a critical role in the control of T cell mediated autoimmunity by suppressing the proliferation and cytokine production of other T cells. To support this hypothesis, it has been found that Foxp3 is mutated in scurfy ( sf ) mice. Cumulative evidence suggests that the 236A/E7 antibody recognizes epitopes from both isoforms of Exon 2 alternatively-spliced variants and is located in the region between Exon 2 and the Zn/LZ domains (aa 105-235).

TRUSTED_SUSTAINABILITY

Specifications

Antigen FoxP3
Applications Flow Cytometry
Classification Monoclonal
Clone 236A/E7
Conjugate Alexa Fluor 488
Description Forkhead box protein P3; Scurfin; AIID; IPEX; JM2; DIETER; PIDX; XPID
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human full-length FoxP3 Recombinant Protein
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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