Foxp3 Rat anti-Mouse, Alexa Fluor 647, Clone: R16-715, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 563486
The R16-715 monoclonal antibody specifically binds to mouse Foxp3. Foxp3 is a 50-55 kDa protein also known as Forkhead box P3, JM2, IPEX, Scurfin, andSf. It is a member of the forkhead or winged helix family of transcription factors and is specifically expressed by T regulatory (Treg) cells. Foxp3 is a key regulatory protein for Treg cell development and function. Ectopic expression of Foxp3 in conventional T cells is sufficient to induce suppressive activity, repress the production of cytokines such as IL2 and IFN-γ, and upregulate Treg cell-associated molecules such as CD25, CTLA4 and GITR. It has been found that the mutation of Foxp3 is responsible for “scurfy” mice. When overexpressed, Foxp3 leads to poor T cell proliferation and activation.
|Alexa Fluor 647|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Forkhead box P3; IPEX; Forkhead box protein P3; JM2; Scurfin; Scurfy; Sf|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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