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FOXP3 Mouse anti-Human, Mouse, FITC, Clone: 3G3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141628

Catalog No. 01-676-621


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Description

Description

MA1-41628 is derived from full-length His-tagged mouse FOXP3.  The precise epitope is not known, but it has been mapped to the N-terminal portion of the protein.

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
Specifications

Specifications

FOXP3
Monoclonal
FITC
FOXP3
Liquid
FOXP3
Full-length, His-tagged murine FOXP3.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse
Flow Cytometry
3G3
50mM sodium borate with 0.05% sodium azide
Q9BZS1, Q99JB6
Scurfin
Mouse
IgG1, kappa
100 Tests
4° C, store in dark
Primary
20371, 50943
Documents
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