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FOXP3 Rat anti-Mouse, PerCP-Cy5.5, Clone: R16-715, BD

Catalog No. BDB563902 Shop All BD Biosciences Products
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BDB563902 50 μg
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Catalog No. BDB563902 Supplier BD Biosciences Supplier No. 563902
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Description

Rat Monoclonal Antibody

The R16-715 monoclonal antibody specifically binds to mouse Foxp3. Foxp3 is a 50-55 kDa protein also known as Forkhead box P3, JM2, IPEX, Scurfin, and Sf. It is a member of the forkhead or winged helix family of transcription factors and is specifically expressed by T regulatory (Treg) cells. Foxp3 is a key regulatory protein for Treg cell development and function. Ectopic expression of Foxp3 in conventional T cells is sufficient to induce suppressive activity, repress the production of cytokines such as IL2 and IFN-γ, and upregulate Treg cell-a ssociated molecules such as CD25, CTLA4 and GITR. It has been found that the mutation of Foxp3 is responsible for “scurfy” mice. When overexpressed, Foxp3 leads to poor T cell proliferation and activation.

TRUSTED_SUSTAINABILITY

Specifications

Antigen FOXP3
Applications Flow Cytometry
Classification Monoclonal
Clone R16-715
Concentration 0.2mg/mL
Conjugate PerCP-Cyanine5.5
Description Forkhead box P3; IPEX; Forkhead box protein P3; JM2; Scurfin; Scurfy; Sf
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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