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Foxp3 Rat anti-Mouse, PE, Clone: MF23, BD

Catalog No. BDB560408 Shop All BD Biosciences Products
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0.1 mg
25 μg
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BDB560408 0.1 mg
BDB560414 25 μg
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Catalog No. BDB560408 Supplier BD Biosciences Supplier No. 560408
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Description

Rat Monoclonal Antibody

Foxp3 is a 50-55kDa protein also known as Forkhead box P3, JM2, or IPEX. It is a member of the forkhead or winged helix family of transcription factors and is specifically expressed by T regulatory (Treg) cells. Foxp3 has been reported to be a key regulatory protein for Treg cell development and function. Ectopic expression of Foxp3 in conventional T cells is sufficient to induce suppressive activity, repress the production of cytokines such as IL2 and IFN-γ, and upregulate Treg cell-associated molecules such as CD25, CTLA4 and GITR. It has been found that the mutation of Foxp3 is responsible for “scurfy” mice. When overexpressed, Foxp3 leads to poor T cell proliferation and activation.
Monoclonal antibody MF23 reacts with mouse Foxp3. Immunoblotting with MF23 antibody has confirmed it recognizes an epitope between 1-87 amino acids in the N-terminal domain.

Host Species: Rat
Clone: MF23
Isotype: IgG2b
Species Reactivity: Mouse
Immunogen: Mouse Foxp3 Recombinant Protein

Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen Foxp3
Applications Flow Cytometry
Classification Monoclonal
Clone MF23
Concentration 0.2mg/mL
Conjugate PE
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse Foxp3 Recombinant Protein
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b
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For Research Use Only.

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