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GAD65 Mouse, Unlabeled, Clone: GAD-6, BD

Catalog No. BDB559931 Shop All BD Biosciences Products
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Catalog No. BDB559931 Supplier BD Biosciences Supplier No. 559931
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Description

Mouse Monoclonal Antibody

γ-aminobutyric acid (GABA) is an amino acid neurotransmitter that is considered to be the major inhibitory neurotransmitter in the mammalian central nervous system. The highest concentrations of GABA are found in the brain, where it is synthesized from glutamic acid to GABA by an enzyme called glutamic acid decarboxylase (GAD). GAD is also expressed in the insulin-producing β cells of the islets of Langerhans. Two isoforms of GAD are present in rat brain, GAD65 and GAD67, based on their relative molecular weight in kDa. Both isoforms have significant levels of homology in the catalytic portion of the molecule, but differ greatly in the first 95 amino acids in the N-terminal region. GAD65 migrates at ∽65 kDa in SDS/PAGE. The antibody is reported to recognize rat, human, mouse, and pig GAD65. Purified GAD65 from rat brain was used as the immunogen. The specific epitope recognized by this clone is a linear epitope localized in the last 41 amino acids of GAD65.

TRUSTED_SUSTAINABILITY

Specifications

Antigen GAD65
Applications Western Blot
Classification Monoclonal
Clone GAD-6
Concentration 0.5mg/mL
Conjugate Unconjugated
Description Glutamic acid decarboxylase
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Purified Rat GAD65
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human, Mouse, Pig, Rat
Content And Storage Store undiluted at 4°C
Isotype IgG2a
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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