MilliporeSigma™ anti-Galectin-9 Clone: 1G3,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABT833

Catalog No. MABT833MI

Description

Specifically detects Galectin-9 Clone: 1G3 in Human samples, and it is validated for ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blotting

Galectin-9 (UniProt O00182; also known as Ecalectin, Gal-9, Tumor antigen HOM-HD-21, Urate transporter/channel protein) is encoded by the LGALS9 (also known as HUAT, LGALS9A) gene (Gene ID 3965) in human. The beta-galactoside-binding lectin, Galectin-9, possesses two distinct carbohydrate recognition domains (CRDs) linked together by a peptide domain of different length among the S, M, and L spliced isoforms. Galectin-9 plays a key role in a negative feed-back mechanism against Th1 immune response, where galectin-9 production from various cell types (e.g. fibroblasts and endothelial cells) is induced by interferon-gamma produced by CD4+ Th1 lymphocytes. The up-regulated galectin-9 in turn suppresses CD4+ Th1 lymphocytes, at least in part through stimulation of the Tim-3 receptor. The Tim-3 receptor on CD4+ Th1 cells from patients with multiple sclerosis (MS), rheumatoid arthritis, and auto-immune hepatitis is defective in its response to galectin-9. In addition, excessive galectin-9 production is reported in two human diseases associated with oncogenic viruses, nasopharyngeal carcinomas (NPC) associated with the Epstein-Barr virus (EBV) and chronic infection by the hepatitis C virus (HCV).

Specifications

• Antigen: Galectin-9
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene Accession No.: O00182
• Host Species: Mouse
• Purification Method: Protein G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Clone 1G3 reacts with all three (L, M, and S) galectin-9 isoforms, but not galectin 1, 2, 3, 4, 7, 8, or 10.
• Content And Storage: 2°C to 8°C for one year from date of shipment
• Isotype: IgG1 κ

• Applications: ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Clone: 1G3
• Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: LGALS9
• Immunogen: GST-tagged recombinant protein corresponding to human Galectin-9.
• Quantity: 100 μg
• Research Discipline: Cell Structure
• Gene ID (Entrez): NP_033665
• Target Species: Human
• Form: Purified

For Research Use Only