GARP Mouse anti-Human, Brilliant Violet 711, Clone: 7B11, BD

Catalog No.	Quantity
BDB563958	100 Tests

Catalog No. BDB563958 Supplier BD Biosciences Supplier No. 563958

Description

Mouse Monoclonal Antibody

The 7B11 (also known as CMSSC-7B11) monoclonal antibody specifically binds to human GARP (Glycoprotein A repetitions predominant). The LRRC32 (Leucine rich repeat containing 32) gene encodes the 662 amino acid-residue, 80 kDa transmembrane GARP glycoprotein that has an extracellular region composed primarily of 20 leucine-rich repeats. GARP is specifically expressed on Treg cells activated through the T cell receptor (TCR). Ectopic expression of GARP in human naοve T cells inhibited their proliferation and cytokine secretion upon TCR activation. Remarkably, GARP over-expression in naοve T cells induced expression of FoxP3 and endowed them with a partial suppressive function. The extracellular, but not the cytoplasmic region, of GARP was necessary for these functions. GARP serves as a receptor for latent TGF-beta which may play a role in the suppressive action of Treg cells. GARP is also expressed on platelets and other tissues, however the function on these cells is not known.

Specifications

• Antigen: GARP
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 7B11
• Conjugate: Brilliant Violet 711
• Description: LRRC32; Garpin; Glycoprotein A repetitions predominant
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Recombinant Human LRRC32
• Purification Method: Affinity Purified
• Quantity: 100 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG2b κ