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GARP Mouse anti-Human, Brilliant Violet 711, Clone: 7B11, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 563958

Catalog No. BDB563958

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The 7B11 (also known as CMSSC-7B11) monoclonal antibody specifically binds to human GARP (Glycoprotein A repetitions predominant). The LRRC32 (Leucine rich repeat containing 32) gene encodes the 662 amino acid-residue, 80 kDa transmembrane GARP glycoprotein that has an extracellular region composed primarily of 20 leucine-rich repeats. GARP is specifically expressed on Treg cells activated through the T cell receptor (TCR). Ectopic expression of GARP in human naοve T cells inhibited their proliferation and cytokine secretion upon TCR activation. Remarkably, GARP over-expression in naοve T cells induced expression of FoxP3 and endowed them with a partial suppressive function. The extracellular, but not the cytoplasmic region, of GARP was necessary for these functions. GARP serves as a receptor for latent TGF-beta which may play a role in the suppressive action of Treg cells. GARP is also expressed on platelets and other tissues, however the function on these cells is not known.



LRRC32; Garpin; Glycoprotein A repetitions predominant
Affinity Purified
Recombinant Human LRRC32
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
Brilliant Violet 711
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IgG2b, κ
Product Certifications


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