GCK, Mouse, Clone: 3C7, Abnova™

Catalog No.	Quantity
89-022-289	100 μg

Catalog No. 89-022-289 Supplier Abnova Corporation Supplier No. H00002645M01

Description

Mouse monoclonal antibody raised against a partial recombinant GCK.

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with noninsulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq

Sequence: GLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ

Specifications

• Antigen: GCK
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 3C7
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a partial recombinant GCK.
• Formulation: PBS with no preservative; pH 7.4
• Gene: GCK
• Gene Accession No.: BC001890.1
• Gene Alias: GK/GLK/HHF3/HK4/HKIV/HXKP/MODY2
• Gene Symbols: GCK
• Host Species: Mouse
• Immunogen: GCK (AAH01890.1, 356 a.a. ∼ 465 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2645
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ