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Description
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. [provided by RefSeq
Specifications
Specifications
| Antigen | GCLC |
| Applications | ELISA, Immunofluorescence, Western Blot |
| Classification | Monoclonal |
| Clone | 3H1 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against a partial recombinant GCLC. |
| Formulation | PBS with no preservative; pH 7.4 |
| Gene | GCLC |
| Gene Accession No. | NM_001498 |
| Gene Alias | GCS/GLCL/GLCLC |
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