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GCLC, Mouse, Clone: 3H1, Abnova™

Catalog No. 89022316 Shop All Abnova Corporation Products
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89-022-316 100 μg
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Catalog No. 89-022-316 Supplier Abnova Corporation Supplier No. H00002729M01
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Mouse monoclonal antibody raised against a partial recombinant GCLC.

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. [provided by RefSeq

Sequence: EGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN

Specifications

Antigen GCLC
Applications ELISA, Immunofluorescence, Western Blot
Classification Monoclonal
Clone 3H1
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against a partial recombinant GCLC.
Formulation PBS with no preservative; pH 7.4
Gene GCLC
Gene Accession No. NM_001498
Gene Alias GCS/GLCL/GLCLC
Gene Symbols GCLC
Host Species Mouse
Immunogen GCLC (NP_001489, 528 a.a. ∼ 637 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2729
Target Species Human
Content And Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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