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GILT Mouse anti-Mouse, PE, Clone: MaP.mGILT6, BD

Catalog No. BDB564875 Shop All BD Biosciences Products
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BDB564875 50 μg
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Catalog No. BDB564875 Supplier BD Biosciences Supplier No. 564875

Description

Mouse Monoclonal Antibody

The MaP.mGILT6 monoclonal antibody specifically binds to mouse Gamma-interferon-inducible lysosomal thiol reductase (GILT). GILT is encoded by Interferon gamma inducible protein 30 ( Ifi30 ). This enzyme, also known as Lysosomal thiol reductase IP30, functions in the endocytic pathway by reducing protein disulfide bonds and facilitating protein unfolding. GILT is constitutively expressed at various levels in macrophages, dendritic cells, B cells, thymocytes, and T cells, and is induced by interferon gamma in other cell types. Enzymatically active GILT dimers can also be secreted by macrophages in response to bacterial stimulation. This enzyme plays an important role in MHC class II-restricted antigen processing and can promote MHC class I-restricted presentation as well.

TRUSTED_SUSTAINABILITY

Specifications

Antigen GILT
Applications Flow Cytometry
Classification Monoclonal
Clone MaP.mGILT6
Concentration 0.2mg/mL
Conjugate PE
Description Ifi30, GILT, Ip30
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Mouse GILT Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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