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Girdin Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520869

Catalog No. PIPA520869


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Description

Description

A suggested positive control is rat brain tissue lysate. PA5-20869 can be used with blocking peptide PEP-0983.

Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development; depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.
Specifications

Specifications

Girdin
Polyclonal
Unconjugated
CCDC88A
Liquid
CCDC88A
A 16 amino acid peptide from near the carboxy terminus human Girdin.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q3V6T2, Q5SNZ0
APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212; AKT-phosphorylation enhancer; Galpha-interacting vesicle-associated protein; G{alpha}-interacting vesicle-associated protein; Hook-related protein 1; akt phosphorylation enhancer; coiled-coil domain-containing protein 88A; g alpha-interacting vesicle-associated protein; girders of actin filament; girdin
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
108686, 305605, 55704
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